Show simple item record

dc.contributor.authorPeris Martínez, Cristina Paloma 
dc.contributor.authorPiá Ludeña, José Vicente
dc.contributor.authorRoig Revert, Maria José
dc.contributor.authorFernández López, Ester
dc.contributor.authorDomingo, Joan Carles
dc.date.accessioned2024-02-12T13:33:11Z
dc.date.available2024-02-12T13:33:11Z
dc.date.issued2023-03-06
dc.identifier.citationPeris-Martínez, C.; Piá-Ludeña, J.V.; Rog-Revert, M.J.; Fernández-López, E.; Domingo, J.C. Antioxidant and Anti-Inflammatory Effects of Oral Supplementation with a Highly-Concentrated Docosahexaenoic Acid (DHA) Triglyceride in Patients with Keratoconus: A Randomized Controlled Preliminary Study. Nutrients 2023, 15, 1300. https:// doi.org/10.3390/nu15051300en
dc.identifier.urihttp://hdl.handle.net/20.500.12466/3984
dc.description.abstractA prospective, randomized, single-center preliminary study was performed in patients with keratoconus stages I–III (Amsler–Krumeich), who received a high rich docosahexaenoic acid (DHA) (1000 mg/day) supplement for 3 months versus untreated patients. One eye per patient was evaluated. Thirty-four patients were recruited (75% men, mean age 31 years), with 15 randomized to the control group and 19 to the DHA-treated group. Corneal topography variables and plasma biomarkers of oxidative stress and inflammatory status were evaluated. A panel of fatty acids in blood samples was also assessed. There were significant between-group differences in the astigmatism axis, asphericity coefficient, and intraocular pressure in favor of the DHA group. Additionally, between-group significant differences in total antioxidant capacity (TAC), malondialdehyde (MDA), free glutathione (GSH) and GSH/GSSG ratio, as well as reduced values of inflammatory markers, including interleukin (IL)-4, IL-6, and vascular endothelial growth factor (VEGF-A) were found. These preliminary findings support the usefulness of the antioxidant and anti-inflammatory effects of DHA supplementation for targeting underlying pathophysiological mechanisms of keratoconus. Prolonged duration of DHA supplementation may be needed to detect more noticeable clinical changes in corneal topographyen
dc.language.isoenges
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.sourcehttps://www.mdpi.com/journal/nutrientses
dc.titleAntioxidant and Anti-Inflammatory Effects of Oral Supplementation with a Highly-Concentrated Docosahexaenoic Acid (DHA) Triglyceride in Patients with Keratoconus: A Randomized Controlled Preliminary Studyen
dc.typearticlees
dc.description.disciplineMedicinaes
dc.identifier.doihttps://doi.org/10.3390/nu15051300
dc.identifier.essn2072-6643
dc.issue.number5es
dc.journal.titleNutrientses
dc.page.initial1es
dc.page.final13es
dc.rights.accessRightsopenAccesses
dc.subject.keywordkeratoconusen
dc.subject.keywordDocosahexaenoic aciden
dc.subject.keywordOxidative stressen
dc.subject.keywordOmega-3 fatty acidsen
dc.subject.keywordAnti-inflammatoryen
dc.volume.number15es
dc.subject.unesco3201.09 Oftalmologíaes
dc.subject.unesco3206 Ciencias de la Nutriciónes


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Atribución 4.0 Internacional
Except where otherwise noted, this item's license is described as Atribución 4.0 Internacional