Maternal-foetal immunity: an admirable design in favour of life

Abstract

Modulation of the maternal-foetal immune response, designed to benefit the gestation of an individual whose genetic material is foreign to that of the mother, since 50% is of paternal origin, is a unique, highly complex biological process involving the father, mother and child. The first signals emitted by the seminal fluid already promote the beginning of immune adaptation, in which the antigens subsequently expressed by the foetus and the sequence of humoral and cellular mechanisms that the mother will be responsible for in the last trimester, will shape an environment of homeostatic balance, in which immune tolerance processes aimed at protecting the new, fragile incipient life will take place.